Sickle cell disease severity: an introduction
نویسندگان
چکیده
منابع مشابه
Intracardiac Thrombosis in Sickle Cell Disease
In patients with sickle cell disease, thrombotic microangiopathy is a rare complication. Also in sickle cell disease, intracardiac thrombus formation without structural heart diseases or atrial arrhythmias is a rare phenomenon. We herein describe a 22-year-old woman, who was a known case of sickle cell-βthalassemia, had a history of recent missed abortion, and was admitted with a vaso-occlusive...
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The search for predictive biomarkers of disease has largely focused on molecular indicators; however, mechanical and biophysical markers, which can integrate multiple pathways across length scales, may provide a more global picture of the underlying pathophysiology. Sickle cell disease, the first disease to have its molecular origins decoded, affects millions of people worldwide and has been st...
متن کاملInformant discrepancy in perceptions of sickle cell disease severity.
OBJECTIVES To evaluate whether informants (children, caregivers, and physicians) differ in their perceptions of chronic disease severity and the extent to which these differences can be explained by objective indices of disease severity, and adjustment of the caregiver. METHODS Participants were 58 children and adolescents between the ages of 8 and 18 years diagnosed with sickle cell disease....
متن کاملThe Study of COVID-19 in an Iranian Family with Sickle Cell Disease
Coronavirus Disease 2019 (COVID-19) is a significant medical and public health problem in the world. It is believed that it can worsen in extreme conditions. Also, it is suggested that blood disorders such as sickle cell disease (SCD) may increase the risk of COVID-19 symptoms. The present study reports a family facing COVID-19, in which one of two members with SCD presented with fever, repeate...
متن کاملIntroduction: anti-adhesion therapy in sickle cell disease.
In this issue of Blood, Kaul et al1 report that stimulation by platelet-activating factor (PAF) of artificially perfused rat mesocecum ex vivo promotes the adhesion of human sickle red blood cells (SS RBC) to postcapillary endothelium. Notably, this adhesive interaction was blocked by two different monoclonal antibodies (MoAbs) to endothelial aVb3 integrin receptor, with resulting improvement i...
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ژورنال
عنوان ژورنال: Experimental Biology and Medicine
سال: 2016
ISSN: 1535-3702,1535-3699
DOI: 10.1177/1535370216641880